Denis Burdakov: Publications

  • Blomeley, C; Garau, C and Burdakov, D (2018)
    Accumbal D2 cells orchestrate innate risk-avoidance according to orexin signals.
    Nature Neuroscience 21, 29-32 PubMed abstract
  • Kosse, C and Burdakov, D (2018)
    Fast and slow oscillations recruit molecularly-distinct subnetworks of lateral hypothalamic neurons in situ.
    eNeuro 5, e0012-0018.2018 PubMed abstract
  • Cains, S; Blomeley, C; Kollo, M; Rácz, R and Burdakov, D (2017)
    Agrp neuron activity is required for alcohol-induced overeating.
    Nature Communications 8, 14014 PubMed abstract
  • Carus-Cadavieco, M; Gorbati, M; Ye, L; Bender, F; van der Veldt, S; Kosse, C; Börgers, C; Lee, SY; Ramakrishnan, C; Hu, Y; Denisova, N; Ramm, F; Volitaki, E; Burdakov, D; Deisseroth, K; Ponomarenko, A and Korotkova, T (2017)
    Gamma oscillations organize top-down signalling to hypothalamus and enable food seeking.
    Nature 542, 232-236 PubMed abstract
  • Gutierrez Herrera, C; Ponomarenko, A; Korotkova, T; Burdakov, D and Adamantidis, A (2017)
    Sleep & metabolism: the multitasking ability of lateral hypothalamic inhibitory circuitries.
    Frontiers in Neuroendocrinology 44, 27-34 PubMed abstract
  • Harris, JJ and Reynell, C (2017)
    How do antidepressants influence the BOLD signal in the developing brain?
    Developmental Cognitive Neuroscience 25, 45-57 PubMed abstract
  • Karnani, MM and Jackson, J (2017)
    Interneuron cooperativity in cortical circuits.
    Neuroscientist [Epub ahead of print] PubMed abstract
  • Kosse, C; Schöne, C; Bracey, E and Burdakov, D (2017)
    Orexin-driven GAD65 network of the lateral hypothalamus sets physical activity in mice.
    Proceedings of the National Academy of Sciences of the United States of America 114, 4525-4530 PubMed abstract
  • Lecca, S; Meye, FJ; Trusel, M; Tchenio, A; Harris, J; Schwarz, MK; Burdakov, D; Georges, F and Mameli, M (2017)
    Aversive stimuli drive hypothalamus-to-habenula excitation to promote escape behavior.
    eLife 6, e30697 PubMed abstract
  • Schöne, C and Burdakov, D (2017)
    Orexin/hypocretin and organizing principles for a diversity of wake-promoting neurons in the brain.
    Current Topics in Behavioral Neurosciences 33, 51-74 PubMed abstract
  • Aitta-aho, T; Pappa, E; Burdakov, D and Apergis-Schoute, J (2016)
    Cellular activation of hypothalamic hypocretin/orexin neurons facilitates short-term spatial memory in mice.
    Neurobiology of Learning and Memory 136, 183-188 PubMed abstract
  • González, JA; Iordanidou, P; Strom, M; Adamantidis, A and Burdakov, D (2016)
    Awake dynamics and brain-wide direct inputs of hypothalamic MCH and orexin networks.
    Nature Communications 7, 11395 PubMed abstract
  • González, JA; Jensen, LT; Iordanidou, P; Strom, M; Fugger, L and Burdakov, D (2016)
    Inhibitory interplay between orexin neurons and eating.
    Current Biology 26, 2486-2491 PubMed abstract
  • Iordanidou, P and Burdakov, D (2016)
    Brain glucose feedback predicts food choice (Commentary on Wakabayashi et al.).
    European Journal of Neuroscience 43, 1420-1421 PubMed abstract
  • Apergis-Schoute, J; Iordanidou, P; Faure, C; Jego, S; Schöne, C; Aitta-Aho, T; Adamantidis, A and Burdakov, D (2015)
    Optogenetic evidence for inhibitory signaling from orexin to MCH neurons via local microcircuits.
    Journal of Neuroscience 35, 5435-5441 PubMed abstract
  • Kosse, C; Gonzalez, A and Burdakov, D (2015)
    Predictive models of glucose control: roles for glucose-sensing neurones.
    Acta Physiologica 213, 7-18 PubMed abstract
  • Kubasova, N; Burdakov, D and Domingos, AI (2015)
    Sweet and low on leptin: hormonal regulation of sweet taste buds.
    Diabetes 64, 3651-3652 PubMed abstract
  • Patel, AX and Burdakov, D (2015)
    Mechanisms of gain control by voltage-gated channels in intrinsically-firing neurons.
    PLOS ONE 10, e0115431 PubMed abstract
  • Belle, MDC; Hughes, ATL; Bechtold, DA; Cunningham, P; Pierucci, M; Burdakov, D and Piggins, HD (2014)
    Acute suppressive and long-term phase modulation actions of orexin on the mammalian circadian clock.
    Journal of Neuroscience 34, 3607-3621 PubMed abstract
  • Burke, LK; Doslikova, B; D'Agostino, G; Garfield, AS; Farooq, G; Burdakov, D; Low, MJ; Rubinstein, M; Evans, ML; Billups, B and Heisler, LK (2014)
    5-HT obesity medication efficacy via POMC activation is maintained during aging.
    Endocrinology 155, 3732-3738 PubMed abstract
  • Kosse, C and Burdakov, D (2014)
    A unifying computational framework for stability and flexibility of arousal.
    Frontiers in Systems Neuroscience 8, 192 PubMed abstract
  • Schöne, C; Apergis-Schoute, J; Sakurai, T; Adamantidis, A and Burdakov, D (2014)
    Coreleased orexin and glutamate evoke nonredundant spike outputs and computations in histamine neurons.
    Cell Reports 7, 697-704 PubMed abstract
  • Burdakov, D; Karnani, MM and Gonzalez, A (2013)
    Lateral hypothalamus as a sensor-regulator in respiratory and metabolic control.
    Physiology & Behavior 121, 117-124 PubMed abstract
  • Jego, S; Glasgow, SD; Herrera, CG; Ekstrand, M; Reed, SJ; Boyce, R; Friedman, J; Burdakov, D and Adamantidis, AR (2013)
    Optogenetic identification of a rapid eye movement sleep modulatory circuit in the hypothalamus.
    Nature Neuroscience 16, 1637-1643 PubMed abstract
  • Karnani, MM; Szabó, G; Erdélyi, F and Burdakov, D (2013)
    Lateral hypothalamic GAD65 neurons are spontaneously firing and distinct from orexin- and melanin-concentrating hormone neurons.
    Journal of Physiology 591, 933-953 PubMed abstract
  • Gonzalez, JA; Jensen, LT; Fugger, L and Burdakov, D (2012)
    Convergent inputs from electrically and topographically distinct orexin cells to locus coeruleus and ventral tegmental area.
    European Journal of Neuroscience 35, 1426-1432 PubMed abstract
  • Patel, AX; Murphy, N and Burdakov, D (2012)
    Tuning low-voltage-activated A-current for silent gain modulation.
    Neural Computation 24, 3181-3190 PubMed abstract
  • Schöne, C and Burdakov, D (2012)
    Glutamate and GABA as rapid effectors of hypothalamic "peptidergic" neurons.
    Frontiers in Behavioral Neuroscience 6, 0081 PubMed abstract
  • Schöne, C; Cao, ZFH; Apergis-Schoute, J; Adamantidis, A; Sakurai, T and Burdakov, D (2012)
    Optogenetic probing of fast glutamatergic transmission from hypocretin/orexin to histamine neurons in situ.
    Journal of Neuroscience 32, 12437-12443 PubMed abstract
  • Cao, ZFH; Burdakov, D and Sarnyai, Z (2011)
    Optogenetics: potentials for addiction research.
    Addiction Biology 16, 519-531 PubMed abstract
  • Karnani, M and Burdakov, D (2011)
    Multiple hypothalamic circuits sense and regulate glucose levels.
    American Journal of Physiology. Regulatory, Integrative and Comparative Physiology 300, R47-55 PubMed abstract
  • Karnani, MM; Apergis-Schoute, J; Adamantidis, A; Jensen, LT; de Lecea, L; Fugger, L and Burdakov, D (2011)
    Activation of central orexin/hypocretin neurons by dietary amino acids.
    Neuron 72, 616-629 PubMed abstract
  • Karnani, MM; Venner, A; Jensen, LT; Fugger, L and Burdakov, D (2011)
    Direct and indirect control of orexin/hypocretin neurons by glycine receptors.
    Journal of Physiology 589, 639-651 PubMed abstract
  • Lam, DD; Leinninger, GM; Louis, GW; Garfield, AS; Marston, OJ; Leshan, RL; Scheller, EL; Christensen, L; Donato, J, Jr.; Xia, J; Evans, ML; Elias, C; Dalley, JW; Burdakov, DI; Myers, MG, Jr. and Heisler, LK (2011)
    Leptin does not directly affect CNS serotonin neurons to influence appetite.
    Cell Metabolism 13, 584-591 PubMed abstract
  • Marston, OJ; Hurst, P; Evans, ML; Burdakov, DI and Heisler, LK (2011)
    Neuropeptide Y cells represent a distinct glucose-sensing population in the lateral hypothalamus.
    Endocrinology 152, 4046-4052 PubMed abstract
  • Schone, C; Venner, A; Knowles, D; Karnani, MM and Burdakov, D (2011)
    Dichotomous cellular properties of mouse orexin/hypocretin neurons.
    Journal of Physiology 589, 2767-2779 PubMed abstract
  • Venner, A; Karnani, MM; Gonzalez, JA; Jensen, LT; Fugger, L and Burdakov, D (2011)
    Orexin neurons as conditional glucosensors: paradoxical regulation of sugar sensing by intracellular fuels.
    Journal of Physiology 589, 5701-5708 PubMed abstract
  • Williams, RH; Morton, AJ and Burdakov, D (2011)
    Paradoxical function of orexin/hypocretin circuits in a mouse model of Huntington's disease.
    Neurobiology of Disease 42, 438-445 PubMed abstract
  • Burdakov, D and Lesage, F (2010)
    Glucose-induced inhibition: how many ionic mechanisms?
    Acta Physiologica 198, 295-301 PubMed abstract

[Page last updated 1 Jun 2018]

Denis Burdakov

  • Qualifications and history 
  • BA, DPhil, University of Oxford
  • 2004 Royal Society Research Fellow,  University of Cambridge, University of Manchester
  • 2005 Lecturer in Neuroscience,  University of Manchester
  • 2006 University Lecturer, Department of Pharmacology,  University of Cambridge
  • 2007 Affiliated Investigator, Institute for Metabolic Science,  University of Cambridge
  • 2012-15 Programme Leader, Medical Research Council National Institute for Medical Research, London
  • 2015 Group Leader, The Francis Crick Institute