Axel Behrens: Publications

  • Boege, Y; Malehmir, M; Healy, ME; Bettermann, K; Lorentzen, A; Vucur, M; Ahuja, AK; Böhm, F; Mertens, JC; Shimizu, Y; Frick, L; Remouchamps, C; Mutreja, K; Kähne, T; Sundaravinayagam, D; Wolf, MJ; Rehrauer, H; Koppe, C; Speicher, T; Padrissa-Altés, S; Maire, R; Schattenberg, JM; Jeong, J-S; Liu, L; Zwirner, S; Boger, R; Hüser, N; Davis, RJ; Müllhaupt, B; Moch, H; Schulze-Bergkamen, H; Clavien, P-A; Werner, S; Borsig, L; Luther, SA; Jost, PJ; Weinlich, R; Unger, K; Behrens, A; Hillert, L; Dillon, C; Di Virgilio, M; Wallach, D; Dejardin, E; Zender, L; Naumann, M; Walczak, H; Green, DR; Lopes, M; Lavrik, I; Luedde, T; Heikenwalder, M and Weber, A (2017)
    A dual role of caspase-8 in triggering and sensing proliferation-associated DNA damage, a key determinant of liver cancer development.
    Cancer Cell 32, 342-359 e310 PubMed abstract
  • Ferreira, RMM; Sancho, R; Messal, HA; Nye, E; Spencer-Dene, B; Stone, RK; Stamp, G; Rosewell, I; Quaglia, A and Behrens, A (2017)
    Duct- and acinar-derived pancreatic ductal adenocarcinomas show distinct tumor progression and marker expression.
    Cell Reports 21, 966-978 PubMed abstract
  • Merve, A; Acquati, S; Hoeck, J; Jeyapalan, J; Behrens, A and Marino, S (2017)
    Role of Myc in choroid plexus tumour pathogenesis.
    Journal of Pathology 241, S5
  • Ros, S; Flöter, J; Kaymak, I; Da Costa, C; Houddane, A; Dubuis, S; Griffiths, B; Mitter, R; Walz, S; Blake, S; Behrens, A; Brindle, KM; Zamboni, N; Rider, MH and Schulze, A (2017)
    6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 is essential for p53-null cancer cells.
    Oncogene 36, 3287-3299 PubMed abstract
  • Anjos-Afonso, F; Loizou, JI; Bradburn, A; Kanu, N; Purewal, S; Da Costa, C; Bonnet, D and Behrens, A (2016)
    Perturbed hematopoiesis in mice lacking ATMIN.
    Blood 128, 2017-2021 PubMed abstract
  • Anttonen, T; Herranen, A; Virkkala, J; Kirjavainen, A; Elomaa, P; Laos, M; Liang, X; Ylikoski, J; Behrens, A and Pirvola, U (2016)
    c-Jun N-terminal phosphorylation: biomarker for cellular stress rather than cell death in the injured cochlea.
    eNeuro 3, e0047-0016.2016 PubMed abstract
  • Blaas, L; Pucci, F; Messal, HA; Andersson, AB; Ruiz, EJ; Gerling, M; Douagi, I; Spencer-Dene, B; Musch, A; Mitter, R; Bhaw, L; Stone, R; Bornhorst, D; Sesay, AK; Jonkers, J; Stamp, G; Malanchi, I; Toftgård, R and Behrens, A (2016)
    Lgr6 labels a rare population of mammary gland progenitor cells that are able to originate luminal mammary tumours.
    Nature Cell Biology 18, 1346-1356 PubMed abstract
  • Blake, SM; Stricker, SH; Halavach, H; Poetsch, AR; Cresswell, G; Kelly, G; Kanu, N; Marino, S; Luscombe, NM; Pollard, SM and Behrens, A (2016)
    Inactivation of the ATMIN/ATM pathway protects against glioblastoma formation.
    eLife 5, e08711 PubMed abstract
  • Cremona, CA; Sancho, R; Diefenbacher, ME and Behrens, A (2016)
    Fbw7 and its counteracting forces in stem cells and cancer: Oncoproteins in the balance.
    Seminars in Cancer Biology 36, 52-61 PubMed abstract
  • Elbediwy, A; Vincent-Mistiaen, ZI; Spencer-Dene, B; Stone, RK; Boeing, S; Wculek, SK; Cordero, J; Tan, EH; Ridgway, R; Brunton, VG; Sahai, E; Gerhardt, H; Behrens, A; Malanchi, I; Sansom, OJ and Thompson, BJ (2016)
    Integrin signalling regulates YAP and TAZ to control skin homeostasis.
    Development 143, 1674-1687 PubMed abstract
  • Gruber, R; Panayiotou, R; Nye, E; Spencer-Dene, B; Stamp, G and Behrens, A (2016)
    YAP1 and TAZ control pancreatic cancer initiation in mice by direct up-regulation of JAK-STAT3 signaling.
    Gastroenterology 151, 526-539 PubMed abstract
  • Merve, A; Acquati, S; Hoeck, J; Jeyapalan, J; Behrens, A and Marino, S (2016)
    c-Myc in choroid plexus tumourigenesis.
    Neuropathology and Applied Neurobiology 42, 21, Abstract O18
  • Chakraborty, A; Diefenbacher, ME; Mylona, A; Kassel, O and Behrens, A (2015)
    The E3 ubiquitin ligase Trim7 mediates c-Jun/AP-1 activation by Ras signalling.
    Nature Communications 6, 6782 PubMed abstract
  • Diefenbacher, ME; Chakraborty, A; Blake, SM; Mitter, R; Popov, N; Eilers, M and Behrens, A (2015)
    Usp28 counteracts Fbw7 in intestinal homeostasis and cancer.
    Cancer Research 75, 1181-1186 PubMed abstract
  • Kanu, N; Zhang, T; Burrell, RA; Chakraborty, A; Cronshaw, J; Da Costa, C; Grönroos, E; Pemberton, HN; Anderton, E; Gonzalez, L; Sabbioneda, S; Ulrich, HD; Swanton, C and Behrens, A (2015)
    RAD18, WRNIP1 and ATMIN promote ATM signalling in response to replication stress.
    Oncogene 35, 4009-4019 PubMed abstract
  • Prochazkova, J; Sakaguchi, S; Owusu, M; Mazouzi, A; Wiedner, M; Velimezi, G; Moder, M; Turchinovich, G; Hladik, A; Gurnhofer, E; Hayday, A; Behrens, A; Knapp, S; Kenner, L; Ellmeier, W and Loizou, JI (2015)
    DNA repair cofactors ATMIN and NBS1 are required to suppress T cell activation.
    PLOS Genetics 11, e1005645 PubMed abstract
  • Sancho, R; Cremona, CA and Behrens, A (2015)
    Stem cell and progenitor fate in the mammalian intestine: Notch and lateral inhibition in homeostasis and disease.
    EMBO Reports 16, 571-581 PubMed abstract
  • Behrens, A; van Deursen, JM; Rudolph, KL and Schumacher, B (2014)
    Impact of genomic damage and ageing on stem cell function.
    Nature Cell Biology 16, 201-207 PubMed abstract
  • Cremona, CA and Behrens, A (2014)
    ATM signalling and cancer.
    Oncogene 33, 3351-3360 PubMed abstract
  • Davis, H; Lewis, A; Behrens, A and Tomlinson, I (2014)
    Investigation of the atypical FBXW7 mutation spectrum in human tumours by conditional expression of a heterozygous propellor tip missense allele in the mouse intestines.
    Gut 63, 792-799 PubMed abstract
  • Diefenbacher, ME; Popov, N; Blake, SM; Schülein-Völk, C; Nye, E; Spencer-Dene, B; Jaenicke, LA; Eilers, M and Behrens, A (2014)
    The deubiquitinase USP28 controls intestinal homeostasis and promotes colorectal cancer.
    Journal of Clinical Investigation 124, 3407-3418 PubMed abstract
  • Penicud, K and Behrens, A (2014)
    DMAP1 is an essential regulator of ATM activity and function.
    Oncogene 33, 525-531 PubMed abstract
  • Sancho, R; Gruber, R; Gu, G and Behrens, A (2014)
    Loss of Fbw7 reprograms adult pancreatic ductal cells into α, δ, and β cells.
    Cell Stem Cell 15, 139-153 PubMed abstract
  • Schülein-Völk, C; Wolf, E; Zhu, J; Xu, W; Taranets, L; Hellmann, A; Jänicke, LA; Diefenbacher, ME; Behrens, A; Eilers, M and Popov, N (2014)
    Dual regulation of Fbw7 function and oncogenic transformation by Usp28.
    Cell Reports 9, 1099-1109 PubMed abstract
  • Zhang, T; Cronshaw, J; Kanu, N; Snijders, AP and Behrens, A (2014)
    UBR5-mediated ubiquitination of ATMIN is required for ionizing radiation-induced ATM signaling and function.
    Proceedings of the National Academy of Sciences of the United States of America 111, 12091-12096 PubMed abstract
  • Burrell, RA; McClelland, SE; Endesfelder, D; Groth, P; Weller, M-C; Shaikh, N; Domingo, E; Kanu, N; Dewhurst, SM; Gronroos, E; Chew, SK; Rowan, AJ; Schenk, A; Sheffer, M; Howell, M; Kschischo, M; Behrens, A; Helleday, T; Bartek, J; Tomlinson, IP and Swanton, C (2013)
    Replication stress links structural and numerical cancer chromosomal instability.
    Nature 494, 492-496 PubMed abstract
  • Davies, CC and Behrens, A (2013)
    Arginine methylation: making its mark on AP-1 gene activation.
    Cell Cycle 12, 2333-2334 PubMed abstract
  • Davies, CC; Chakraborty, A; Diefenbacher, ME; Skehel, M and Behrens, A (2013)
    Arginine methylation of the c-Jun coactivator RACO-1 is required for c-Jun/AP-1 activation.
    EMBO Journal 32, 1556-1567 PubMed abstract
  • Sancho, R; Blake, SM; Tendeng, C; Clurman, BE; Lewis, J and Behrens, A (2013)
    Fbw7 repression by Hes5 creates a feedback loop that modulates Notch-mediated intestinal and neural stem cell fate decisions.
    PLOS Biology 11, e1001586 PubMed abstract
  • Arthur-Farraj, PJ; Latouche, M; Wilton, DK; Quintes, S; Chabrol, E; Banerjee, A; Woodhoo, A; Jenkins, B; Rahman, M; Turmaine, M; Wicher, GK; Mitter, R; Greensmith, L; Behrens, A; Raivich, G; Mirsky, R and Jessen, KR (2012)
    c-Jun reprograms Schwann cells of injured nerves to generate a repair cell essential for regeneration.
    Neuron 75, 633-647 PubMed abstract
  • Fontana, X; Hristova, M; Da Costa, C; Patodia, S; Thei, L; Makwana, M; Spencer-Dene, B; Latouche, M; Mirsky, R; Jessen, KR; Klein, R; Raivich, G and Behrens, A (2012)
    c-Jun in Schwann cells promotes axonal regeneration and motoneuron survival via paracrine signaling.
    Journal of Cell Biology 198, 127-141 PubMed abstract
  • Izumi, N; Helker, C; Ehling, M; Behrens, A; Herzog, W and Adams, RH (2012)
    Fbxw7 controls angiogenesis by regulating endothelial Notch activity.
    PLOS ONE 7, e41116 PubMed abstract
  • Kumar, MS; Hancock, DC; Molina-Arcas, M; Steckel, M; East, P; Diefenbacher, M; Armenteros-Monterroso, E; Lassailly, F; Matthews, N; Nye, E; Stamp, G; Behrens, A and Downward, J (2012)
    The GATA2 transcriptional network is requisite for RAS oncogene-driven non-small cell lung cancer.
    Cell 149, 642-655 PubMed abstract
  • Reynolds, N; Latos, P; Hynes-Allen, A; Loos, R; Leaford, D; O'Shaughnessy, A; Mosaku, O; Signolet, J; Brennecke, P; Kalkan, T; Costello, I; Humphreys, P; Mansfield, W; Nakagawa, K; Strouboulis, J; Behrens, A; Bertone, P and Hendrich, B (2012)
    NuRD suppresses pluripotency gene expression to promote transcriptional heterogeneity and lineage commitment.
    Cell Stem Cell 10, 583-594 PubMed abstract
  • Reynolds, N; Salmon-Divon, M; Dvinge, H; Hynes-Allen, A; Balasooriya, G; Leaford, D; Behrens, A; Bertone, P and Hendrich, B (2012)
    NuRD-mediated deacetylation of H3K27 facilitates recruitment of Polycomb Repressive Complex 2 to direct gene repression.
    EMBO Journal 31, 593-605 PubMed abstract
  • Ruff, CA; Staak, N; Patodia, S; Kaswich, M; Rocha-Ferreira, E; Da Costa, C; Brecht, S; Makwana, M; Fontana, X; Hristova, M; Rumajogee, P; Galiano, M; Bohatschek, M; Herdegen, T; Behrens, A and Raivich, G (2012)
    Neuronal c-Jun is required for successful axonal regeneration, but the effects of phosphorylation of its N-terminus are moderate.
    Journal of Neurochemistry 121, 607-618 PubMed abstract
  • Vinuesa, AG; Sancho, R; Garcia-Limones, C; Behrens, A; ten Dijke, P; Calzado, MA and Muñoz, E (2012)
    Vanilloid receptor-1 regulates neurogenic inflammation in colon and protects mice from colon cancer.
    Cancer Research 72, 1705-1716 PubMed abstract
  • Zhang, T; Penicud, K; Bruhn, C; Loizou, JI; Kanu, N; Wang, Z-Q and Behrens, A (2012)
    Competition between NBS1 and ATMIN controls ATM signaling pathway choice.
    Cell Reports 2, 1498-1504 PubMed abstract
  • Aguilera, C; Nakagawa, K; Sancho, R; Chakraborty, A; Hendrich, B and Behrens, A (2011)
    c-Jun N-terminal phosphorylation antagonises recruitment of the Mbd3/NuRD repressor complex.
    Nature 469, 231-235 PubMed abstract
  • Babaei-Jadidi, R; Li, N; Saadeddin, A; Spencer-Dene, B; Jandke, A; Muhammad, B; Ibrahim, EE; Muraleedharan, R; Abuzinadah, M; Davis, H; Lewis, A; Watson, S; Behrens, A; Tomlinson, I and Nateri, AS (2011)
    FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation.
    Journal of Experimental Medicine 208, 295-312 PubMed abstract
  • Davis, H; Lewis, A; Spencer-Dene, B; Tateossian, H; Stamp, G; Behrens, A and Tomlinson, I (2011)
    FBXW7 mutations typically found in human cancers are distinct from null alleles and disrupt lung development.
    Journal of Pathology 224, 180-189 PubMed abstract
  • Jandke, A; Da Costa, C; Sancho, R; Nye, E; Spencer-Dene, B and Behrens, A (2011)
    The F-box protein Fbw7 is required for cerebellar development.
    Developmental Biology 358, 201-212 PubMed abstract
  • Loizou, JI; Sancho, R; Kanu, N; Bolland, DJ; Yang, F; Rada, C; Corcoran, AE and Behrens, A (2011)
    ATMIN is required for maintenance of genomic stability and suppression of B cell lymphoma.
    Cancer Cell 19, 587-600 PubMed abstract
  • Da Costa, CR; Villadiego, J; Sancho, R; Fontana, X; Packham, G; Nateri, AS and Behrens, A (2010)
    Bag1-L is a phosphorylation-dependent coactivator of c-Jun during neuronal apoptosis.
    Molecular and Cellular Biology 30, 3842-3852 PubMed abstract
  • Davies, CC; Chakraborty, A; Cipriani, F; Haigh, K; Haigh, JJ and Behrens, A (2010)
    Identification of a co-activator that links growth factor signalling to c-Jun/AP-1 activation.
    Nature Cell Biology 12, 963-972 PubMed abstract
  • Hoeck, JD; Jandke, A; Blake, SM; Nye, E; Spencer-Dene, B; Brandner, S and Behrens, A (2010)
    Fbw7 controls neural stem cell differentiation and progenitor apoptosis via Notch and c-Jun.
    Nature Neuroscience 13, 1365-1372 PubMed abstract
  • Kanu, N; Penicud, K; Hristova, M; Wong, B; Irvine, E; Plattner, F; Raivich, G and Behrens, A (2010)
    The ATM cofactor ATMIN protects against oxidative stress and accumulation of DNA damage in the aging brain.
    Journal of Biological Chemistry 285, 38534-38542 PubMed abstract
  • Maes, C; Goossens, S; Bartunkova, S; Drogat, B; Coenegrachts, L; Stockmans, I; Moermans, K; Nyabi, O; Haigh, K; Naessens, M; Haenebalcke, L; Tuckermann, JP; Tjwa, M; Carmeliet, P; Mandic, V; David, J-P; Behrens, A; Nagy, A; Carmeliet, G and Haigh, JJ (2010)
    Increased skeletal VEGF enhances β-catenin activity and results in excessively ossified bones.
    EMBO Journal 29, 424-441 PubMed abstract
  • Makwana, M; Werner, A; Acosta-Saltos, A; Gonitel, R; Pararajasingam, A; Ruff, C; Rumajogee, P; Cuthill, D; Galiano, M; Bohatschek, M; Wallace, AS; Anderson, PN; Mayer, U; Behrens, A and Raivich, G (2010)
    Peripheral facial nerve axotomy in mice causes sprouting of motor axons into perineuronal central white matter: time course and molecular characterization.
    Journal of Comparative Neurology 518, 699-721 PubMed abstract
  • Sancho, R; Jandke, A; Davis, H; Diefenbacher, ME; Tomlinson, I and Behrens, A (2010)
    F-box and WD repeat domain-containing 7 regulates intestinal cell lineage commitment and is a haploinsufficient tumor suppressor.
    Gastroenterology 139, 929-941 PubMed abstract

[Page last updated 1 Nov 2017]

Axel Behrens

axel.behrens@crick.ac.uk
+44 (0)20 379 61194

  • Qualifications and history
  • 1998 PhD in Biology, Institute of Molecular Pathology, Austria
  • 1998 Postdoctoral Fellow, Institute of Molecular Pathology, Austria
  • 1999 Postdoctoral Fellow, Institute of Neuropathology, Switzerland
  • 2001 Established lab at the Imperial Cancer Research Fund, UK (in 2002 the Imperial Cancer Research Fund became Cancer Research UK)
  • 2015 Group Leader, the Francis Crick Institute, London, UK