Human brains contain billions of nerve cells, or neurons.
There are huge variations in the structure and form of these
neurons, and even vast differences in properties within the same
structural groups.
Now, scientists have shown for the first time that these
differences are influenced by local connections within information
hubs in the brain, as well as by the different kinds of sensory
information the hubs receive.
Troy Margrie of the MRC's National Institute for Medical
Research (NIMR; now part of the Francis Crick
Institute) explained: "Imagine the cultural and sub-cultural
differences of everyone living in London. Mix them up and randomly
position them across a map of London. These people represent the
neurons in a mammalian brain.
"Now imagine London as a city where the only information coming
in is via the tube lines - with no television, radio, internet or
phones. The Northern line information (for example, smells) is
not only very different to the District line information (such as
sounds) but each stop on the Northern line processes different
kinds of smells. The people who belong to the same information hub
- that is, live around the same tube stop - and receive their own
unique type of information, are far more similar to each other than
to those living at other tube stops and receiving other kinds of
information."
The variations in structure and form - or biophysical properties
- of different neurons affect the tasks they carry out. For
instance, one such biophysical property, called sag potential,
influences the input and output functions of most neurons. In this
study the scientists looked at variability in sag potential in a
part of the brain responsible for processing smells - the olfactory
bulb - where functionally distinct networks of neurons can be
identified.
They found that differences in sag potential across these
networks were not random but were associated with functionally
discrete local circuits. Their findings indicated that interactions
among neurons belonging to the same sensory circuit influenced
their biophysical properties. And cells processing the same kind of
information were more similar than neurons processing different
information.
Dr Margrie said: "This work describes a fundamental organising
principle that underlies biophysical variations in the neurons and
connections in our brains. This new data informs us of the basic
function and adaptive qualities of such circuits that is required
to understand the operation of healthy and diseased brains."
The research was carried out by Dr Margrie's team at University
College London and NIMR. The paper,' A biophysical signature of network affiliation and sensory
processing in mitral cells' is published in
Nature.