The scientific insight, leadership and influence shown by
Douglas Young has been praised by leading tuberculosis researchers
from across the world.
Douglas is retiring at the end of a 40 year research career
seeking to better understand tuberculosis infection and the immune
response the body mounts against the disease-causing bacteria.
Professor Barry Bloom of the Harvard T H Chan School of Public
Health in the USA said: "He has been incredibly creative
scientifically, learning where the moving frontier of science is
going and bringing new cutting edge ideas and technologies to
tuberculosis."
Douglas was Head of the Division of Mycobacterial Research at
the National Institute for Medical Research in Mill Hill, one of
the parent institutes that became the Francis Crick Institute in
2015. He has held research positions around the globe and has been
a respected mentor for many scientists in the field of
tuberculosis.
One third of the global population is infected with the bacteria
that causes tuberculosis, but only 10% of these people will go on
to develop the active disease during their lives.
A complex interplay between the tuberculosis bacteria and the
body's immune system determines whether someone goes on to develop
the disease, or whether the bacteria simply persist in the body
without ever causing any symptoms.
Douglas sought to understand the molecular pathways involved in
disease progression using a combination of immunology and molecular
biology techniques. He played a major role in initiating research
on disease progression that underpins current approaches to
development of new drugs and vaccines for tuberculosis.
His clear articulation of scientific challenges, clarity of
insight and engaging writing style, are particularly singled out by
those working in this area of infection science, including a number
of insightful editorials for the Tuberculosis journal.
Professor Tanya Parish of the Infectious Disease Research
Institute in the USA said: "Douglas has a way of expressing
concepts and complex ideas, not just in an understandable fashion,
but also using the most delightful analogies."
Professor Eric Rubin, from the Harvard T H Chan School of Public
Health, USA, added: "Douglas is a thought leader and an actual
leader, organising fantastically interesting and productive
scientific groups."
Douglas Young completed a DPhil in microbial enzymology at
Oxford University, then spent two years working on leprosy at the
Foundation for Medical Research in Mumbai. After an appointment as
Assistant Professor at the University of Washington in Seattle, he
came back to the UK and positions at Hammersmith Hospital and St
Mary's Hospital Medical School. He helped establish two research
centres at Imperial College London and has chaired several boards
and working groups on tuberculosis. He led a $20 million
international project funded jointly by the Bill & Melinda
Gates Foundation and Wellcome with the goal of developing new drugs
for the treatment of latent tuberculosis.